A new open-access, peer-reviewed paper by ETERNAL indiustrial partner AstraZeneca demonstrates the effective recovery of homogeneous palladium catalysts from reaction mixtures using commercial organic solvent nanofiltration (OSN) membranes. The paper presents a real pharmaceutical manufacturing case study to synthesize AZD4625, without altering the existing catalyst/ligand system. The recovered catalyst and ligand were successfully reused up to five times, maintaining over 90% conversion. Life cycle assessment shows that the sustainability of the process could be further enhanced by using greener bio-derived solvents and implementing solvent recovery to reduce solvent consumption.
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