Separation and purification in organic solvents are indispensable procedures in pharmaceutical manufacturing. Organic solvent nanofiltration (OSN) offers a low energy, low waste generating, and easily scalable alternative to the conventional method sof distillation or chromatography. A newly open-access published review from the research team at ETERNAL partners AstraZeneca comprehensively summarizes the recent progress of organic solvent nanofiltration and its applications in the pharmaceutical industry.

Featuring in the respected ACS journal Organic Process Research & Development, the review concentrates on progress made in the last ten years especially, in the concentration and purification of active pharmaceutical ingredients, homogeneous catalyst recovery, solvent exchange and recovery, and OSN-assisted peptide/oligonucleotide synthesis. The authors then go on to dicuss in detail the challenges and future perspectives of membrane technology in pharmaceutical applications. You can meet the researchers behind this publication in this September 2023 news article from ETERNAL.

We are delighted to report that the review article ‘Organic Solvent Nanofiltration in Pharmaceutical Applications’ has been selected as an “Editor’s Choice” paper by OPR&D, reflecting the judgment that the paper will be of of broad public interest. The full text of the paper is available to freely download from the OPR&D website.

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