Congratulations to researchers at ETERNAL industrial partner AstraZeneca whose recent publication on recovery and reuse of homogeneous palladium catalysts via organic solvent nanofiltration has just been named as a 2025 HOT article by the editorial and review team at RSC Green Chemistry.

This recognition makes the open-access peer-reviewed publication part of a rolling themed collection of the hottest work published in Green Chemistry in the opinion of the journal’s editors and referees. The paper, which demonstrates the successful application of Organic Solvent Nanofiltration (OSN) to the challenge of recovering valuable precious metal based homogeneous catalysts from reaction product mixtures for reuse in the context of a real-world AZ reaction scheme, has already been cited in other published work within a few weeks of its release.

The authors’ work demonstrates the application of OSN under industrially relevant conditions with high catalyst/product concentrations and using the green solvent 2-MeTHF, highlighting its practicality and environmentally friendly nature. LCA indicated that the OSN process using bio-derived 2-MeTHF has a carbon footprint comparable to the adsorption method using CUNO filters. Further sustainability gains can be achieved by integrating a solvent recovery unit to reduce solvent consumption of the OSN diafiltration process. Additionally, future research can extend the findings from this study to other pharmaceutical syntheses. Many congratulations to the joint UK/Swedish based authorial team!

Read the full text open-access article at Green Chemistry