Continuous Lipid-Based Encapsulation

Laboratorio Reig Jofre has introduced a continuous microfluidic platform to produce both diclofenac-loaded liposomes and DNA-loaded lipid nanoparticles (DNA-LNP). Design of experiments (DoE) combined with digital twin simulation of particle properties, enables predictive formulation, reducing the need for physical experimentation.

Final validation of the digital twin for DNA-LNP production is ongoing. In a further step Reig Jofre is exploring the use of a microjet reactor as an alternative to microfluidic chips for potential industrial scale-up. The aspiration is to offer a reproducible and predictive platform applicable to other nanoparticle-based formulations supporting widespread environmentally responsible pharmaceutical innovation.

Find out more in this accessible two-page industrial case study arising from the ETERNAL Horizon Europe Research and Innovation Action.

Download case study now